Antimalarial activity and toxicity evaluation of a quantified Nauclea pobeguinii extract.
Identifieur interne : 001625 ( Main/Exploration ); précédent : 001624; suivant : 001626Antimalarial activity and toxicity evaluation of a quantified Nauclea pobeguinii extract.
Auteurs : Kahunu Mesia ; Richard K. Cimanga ; Liene Dhooghe ; Paul Cos ; Sandra Apers ; Jozef Totté ; Gaston L. Tona ; Luc Pieters ; Arnold J. Vlietinck ; Louis MaesSource :
- Journal of ethnopharmacology [ 1872-7573 ] ; 2010.
Descripteurs français
- KwdFr :
- Animaux, Antipaludiques (isolement et purification), Antipaludiques (toxicité), Attribution aléatoire, Cellules cultivées, Extraits de plantes (isolement et purification), Extraits de plantes (toxicité), Femelle, Humains, Plasmodium falciparum (), Plasmodium falciparum (croissance et développement), Rubiaceae, Souris, Tests de toxicité aigüe (), Tiges de plante, Écorce, Évaluation préclinique de médicament ().
- MESH :
- croissance et développement : Plasmodium falciparum.
- isolement et purification : Antipaludiques, Extraits de plantes.
- toxicité : Antipaludiques, Extraits de plantes.
- Animaux, Attribution aléatoire, Cellules cultivées, Femelle, Humains, Plasmodium falciparum, Rubiaceae, Souris, Tests de toxicité aigüe, Tiges de plante, Écorce, Évaluation préclinique de médicament.
English descriptors
- KwdEn :
- Animals, Antimalarials (isolation & purification), Antimalarials (toxicity), Cells, Cultured, Drug Evaluation, Preclinical (methods), Female, Humans, Mice, Plant Bark, Plant Extracts (isolation & purification), Plant Extracts (toxicity), Plant Stems, Plasmodium falciparum (drug effects), Plasmodium falciparum (growth & development), Random Allocation, Rubiaceae, Toxicity Tests, Acute (methods).
- MESH :
- chemical , isolation & purification : Antimalarials, Plant Extracts.
- chemical , toxicity : Antimalarials, Plant Extracts.
- drug effects : Plasmodium falciparum.
- growth & development : Plasmodium falciparum.
- methods : Drug Evaluation, Preclinical, Toxicity Tests, Acute.
- Animals, Cells, Cultured, Female, Humans, Mice, Plant Bark, Plant Stems, Random Allocation, Rubiaceae.
Abstract
To evaluate the in vitro and in vivo antiplasmodial activity and toxicity of the aqueous and 80% EtOH extract of the stem bark of Nauclea pobeguinii (Pob. Ex. Pell.) Petit (Rubiaceae), a plant used in traditional medicine in DR Congo against malaria.
DOI: 10.1016/j.jep.2010.05.008
PubMed: 20470876
Affiliations:
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Le document en format XML
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Ex. Pell.) Petit (Rubiaceae), a plant used in traditional medicine in DR Congo against malaria.</div></front></TEI><affiliations><list></list><tree><noCountry><name sortKey="Apers, Sandra" sort="Apers, Sandra" uniqKey="Apers S" first="Sandra" last="Apers">Sandra Apers</name><name sortKey="Cimanga, Richard K" sort="Cimanga, Richard K" uniqKey="Cimanga R" first="Richard K" last="Cimanga">Richard K. Cimanga</name><name sortKey="Cos, Paul" sort="Cos, Paul" uniqKey="Cos P" first="Paul" last="Cos">Paul Cos</name><name sortKey="Dhooghe, Liene" sort="Dhooghe, Liene" uniqKey="Dhooghe L" first="Liene" last="Dhooghe">Liene Dhooghe</name><name sortKey="Maes, Louis" sort="Maes, Louis" uniqKey="Maes L" first="Louis" last="Maes">Louis Maes</name><name sortKey="Mesia, Kahunu" sort="Mesia, Kahunu" uniqKey="Mesia K" first="Kahunu" last="Mesia">Kahunu Mesia</name><name sortKey="Pieters, Luc" sort="Pieters, Luc" uniqKey="Pieters L" first="Luc" last="Pieters">Luc Pieters</name><name sortKey="Tona, Gaston L" sort="Tona, Gaston L" uniqKey="Tona G" first="Gaston L" last="Tona">Gaston L. Tona</name><name sortKey="Totte, Jozef" sort="Totte, Jozef" uniqKey="Totte J" first="Jozef" last="Totté">Jozef Totté</name><name sortKey="Vlietinck, Arnold J" sort="Vlietinck, Arnold J" uniqKey="Vlietinck A" first="Arnold J" last="Vlietinck">Arnold J. 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